منابع مشابه
Synthetic heparin.
Robert J Linhardt is Ann and John Broadbent, Jr. ‘59 Senior Constellation Professor of Biocatalysis and Metabolic Engineering at the Rensselaer Polytechnic Institute. His honors include the American Chemical Society Horace S. Isbell, Claude S. Hudson and Melville L. Wolfrom Awards, the AACP Volwiler Research Achievement Award, the USP Award for an Innovative Response to a Public Health Challeng...
متن کاملSynthetic heparin-like antithrombotics
After the discovery of a unique pentasaccharide domain in heparin that is responsible for activation of antithrombin 111, many analogues have been synthesised which stimulate the inhibition of factor Xa. Some aspects of the synthesis of heparin like pentasaccharides are presented. Furthermore, pentasaccharide conjugates could be designed and synthesised which stimulate the antithrombin I11 medi...
متن کاملMicroarrays of synthetic heparin oligosaccharides.
We present the first preparation of microarrays containing synthetic heparin oligosaccharides in order to elucidate the heparin-protein interactions involved in a variety of biological processes. For this purpose, we have developed a novel linker strategy that is compatible with the protecting-group manipulations required for the synthesis of the highly sulfated oligosaccharides and can also be...
متن کاملDextran sulphate--a synthetic analogue of heparin.
The structure of the natural anticoagulant, heparin, is gradually being elucidated. As each step forward is made, attempts to synthesize molecules with the biological activity of heparin receive renewed impetus. It is now known (Jorpes, 1939) that heparin is composed of glucuronic acid and glucosamine though the mode of linkage of these two parts is not yet clear. Some of the hydroxyl groups of...
متن کاملDevelopment of a Synthetic Heparin Pentasaccharide: Fondaparinux.
Fondaparinux (Arixtra®; Sanofi-Synthélabo/Organon) is the first of a new class of antithrombotic agents distinct from low molecular weight (LMW) heparins and heparin. It is a synthetic pentasaccharide mimicking the site of heparin that binds to antithrombin III (AT). It is homogeneous with a molecular weight of 1728 Da. It exhibits only factor (F) Xa inhibitor activity via binding to AT, which ...
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ژورنال
عنوان ژورنال: Current Opinion in Pharmacology
سال: 2012
ISSN: 1471-4892
DOI: 10.1016/j.coph.2011.12.002